Carduso portfolio company VRelax wins prestigious ‘Prix Galien MedTech Innovation Award’ 2021

The Groningen Company VRelax has won a prestigious prize on 19 May. The international Prix Galien Medtech Innovation Award is presented to companies that are introducing meaningful developments in healthcare.

VRelax changes the approach to stress. Thanks to relaxation in Virtual Reality (VR), the lives of people with mental or physical problems are significantly improved. This allows existing therapy to be effectively supported without having to resort to additional medication or intensive supervision. The mission of VRelax: reducing stress and anxiety, distraction from worry or pain and giving people back control, by using fewer pills, and providing more VR solutions within healthcare.

The jury praises the approach of the Groningen start-up for its on-going (clinical) research and validation of the effect of VRelax within mental health care, hospitals and health and safety. The fact that this is done together with patients and scientific healthcare professionals attests to a long-term strategy in which users are central and the correct implementation of technical innovations is guaranteed. The recent CE certification helps enormously in this regard. The jury also appreciates the user-friendliness of the system. The app has a high degree of freedom of choice, allowing the user to choose which virtual environment best suits his / her state of mind at that time.

The jury of the Prix Galien MedTech Innovation Award expresses its sincere admiration for VRelax and their ability to use VR broadly in healthcare. This is a fantastic development for the vulnerable patient, but also for the care provider who is under a lot of stress, especially in COVID time. A development that is important, especially in situations where increasingly vulnerable patients have to be cared for with fewer and fewer people.

Many people suffer from stress, for example due to burnout, depression or anxiety. This results in a lot of personal suffering and high medical costs (CBS, 2019). Reducing stress and learning to relax, are important pillars of good psychological health that help to reduce healthcare costs and reduce medication use.

It is precisely because of the current pandemic that vulnerable groups are more likely to run into mental health problems. VRelax offers many applications during the crisis, but has also been used for much longer to support healthcare professionals and patients. Regular treatments are often a long, intensive process with personal guidance and accompanying medication. VRelax has been developed to offer a good alternative in this regard.

Carduso Capital invests in start-up Notoxins that develops an innovative remedy for excessive sweating.

Excessive sweating, called hyperhydrosis, is a condition that often has no underlying cause. People who suffer from it experience social consequences in particular. Wet sweat stains and unpleasant odours can contribute to isolation and significantly affect personal confidence.

Based on their own dermatological research, Asser Dermatologist Wim Venema and Apotheker Ben Homan have found an active substance that penetrates deep into the skin and can act directly on the sweat glands. The initial results of the study are so promising that it was subsequently decided to set up the company Notoxins and to seek financing for further development into a (eventually) registered medicine. To date, hardly any suitable medication is available to properly treat hyperhydrosis.

Experienced (clinical) pharmacologist Reinier Schwietert has been recruited to provide the so-called clinical proof of concept for the medicinal use of the found product, who will design and supervise the further test program.

With the investment of Carduso Capital, Notoxins can carry out further developments and carry out the clinical tests, which should make the agent suitable for registered development as a registered pharmacotherapeutic treatment in mid-2022.

______________________________________________________________

More information can be found at:
www.notoxins.org
www.cardusocapital.com

For more information please contact:
Notoxins:  Reinier Schwietert, (+31) 6-5114 8308 Email: reinier@woodie-woodie.com
Carduso Capital: Koos Koops, (+31) 6-2298 9098 Email: koos.koops@cardusocapital.com

Carduso en RHM invests in Groningen start-up QDI-Systems ‘Quantum Dots’: the next generation in X-ray technology.

X-rays are a well-known method of looking “in the body” in the hospital for effects such as broken bones. As soon as someone has to have an X-ray, the caregivers stand behind a screen and sometimes a lead apron is put on if necessary. These measures are necessary because continuous exposure to X-rays can be dangerous. Radiation increases the risk of developing cancer. Limiting this radiation is therefore important in all cases.

Quantum dots are nanocrystals, so small that the quantum mechanical effects determine the properties of this material. These unique properties allow efficient capture of X-rays and converting them into electrical charges within the Quantum Dots. These charges are further amplified, converted into digital data and displayed as an image in the screen in front of a radiologist.

Application of Quantum Dots in the X-ray detectors has several advantages: Due to the higher sensitivity, sharper and thus more detailed images can be obtained; more importantly, the amount of radiation can be drastically reduced and the safety of both patient and caregivers is served. The application also lends itself to work with pre-formed detectors; for example, making mammography screening a lot less patient-unfriendly and it also allows the tissue to be photographed from multiple angles ‘in one shot’, so better screening can take place.

QDI is based on knowledge developed and patented at the University of Groningen. With the help of NWO Take-off grant, the knowledge was converted into a scalable business model. The initial technical validation was further supported by SNN VIA subsidy for prototype demonstration. In addition to the financial support from RuG-Holding, Carduso Capital has committed to the company. With this investment, QDI can further develop the proven basic technique in scaling up and prepare for cooperation with industrial leaders.

_________________________________________________________________

For further information:
www.qdisystems.com
www.cardusocapital.com
www.rugholding.nl

For further contact::
QDI Systems:  Artem Shulga, (+31) 6-2600 2038 Email: a.shulga@qdisystems.com
Carduso Capital: Koos Koops, (+31) 6-2298 9098 Email: koos.koops@cardusocapital.com
RuG Holding: Corina prent, (+31) 6-2292 6660 Email: c.s.w.prent@rug.nl

Carduso Capital invests in Groningen startup Ivy Medical to develop a wearable “next generation” infusion pump.

The importance of patient’s mobility has been receiving a lot of attention in recent years. Movement accelerates the recovery of patients after being admitted to the hospital. Unfortunately, patients’ freedom of movement during IV-therapy is hindered by the well-known infusion pole. Ivy Medical offers a solution that tackles this problem.

With the help of an NWO Take-off grant, Ivy Medical was able to research and develop the technology for a new pumping mechanism. Furthermore, Ivy Medical identified several opportunities to improve the current standard of infusion therapy.

Ivy Medical develops a new, multifunctional infusion pump called the “Ivy One”. With the Ivy One, patients no longer have to walk with the infusion pole through corridors, crossing thresholds, and struggle themselves into elevators. The Ivy One can be worn as a shoulder bag, offering high wearing comfort and optimal flexibility during infusion therapy. The Ivy One does not require a drip chamber and can, therefore, operate regardless of its position, whether the patient is walking, sitting or lying down. Less time will be required for the pump to setup and, in addition, fewer alarms are generated, resulting in freedom of movement for patients, an additional cost saving for hospitals and less working pressure for the nursing staff.

With the investment of Carduso Capital, and the support of an Innovation credit, Ivy Medical can further develop Ivy One. After preparation for production the Ivy One is planned to be available to the market in 2022.
_________________________________________________________________

More information can be found at:
www.ivymedical.nl
www.cardusocapital.com

For more information please contact:
Ivy Medical:  Melcher Frankema, (+31) 6-2665 7582 or send an email to: melcher@ivymedical.nl
Carduso Capital: Robert Polano, (+31) 6-1892 7553 or send an email to: robert.polano@cardusocapital.com

Carduso Capital finances the Groningen ViroTact that is developing a rapid, point of care COVID-19 test for the immediate detection of Corona contamination.

ViroTact is at an advanced stage with the development of a COVID-19 test in which a determination is given within 30 seconds about whether or not the coronavirus is present in the tested person. This makes an important contribution to preventing the virus from spreading.

ViroTact uses its proven innovative and patented technology platform and expects to have the test available in 8 weeks.

Containing the virus is essential for the health of individuals and for controlling this global pandemic. According to specialists at John Hopkins and Harvard, tracing the virus through intensive corona infection testing is the only option to tackle the pandemic and get society back on track. To do that safely, the estimation is that more than 5 million tests a day are needed in the US alone.

Current virus detection tests are taking too long, are too expensive and labour intensive, or require specialized equipment and personnel. So there is a need for a quick point of care COVID-19 test.

ViroTact technology is based on the detection of unique proteases that are produced by viruses or bacteria. Infrared light is released in the presence of the viral protease, which is received by a specially designed portable detector and gives an immediate result.

“Thanks to the simple design and portable detector, it is possible to immediately determine whether a person is carrying the virus. Our test can be used point of care, at the general practitioner, at the emergency room or at a mobile test location and, for example, at airports and contributes to containment of the spread of the virus ”, says Joost Gazendam, CEO ViroTact.

Carduso Capital has given a substantial financial injection to accelerate development and time to the market.

Groningen, May 6, 2020

VRelax combats the consequences of Covid-19 by reducing stress with Virtual Reality.

VRelax B.V. joins forces with Carduso Capital B.V. and Triade Investments.

VRelax has found the right investors in Carduso Capital and Triade Investments to further empower care-professionals to reduce stress, burnout and pain within the health sector using Virtual Reality. VRelax offers a solution to the increasing demand for help for remedies against these health complaints.

The number of people suffering from stress in our society grows every year, increasing the costs in healthcare and our society. In addition, the influx of patients puts increasing pressure on healthcare professionals. This changing healthcare landscape therefore offers opportunities for solutions that fit in with this, such as VRelax.

The scientifically validated app was developed together with patients and the University Medical Center Groningen. It offers a wide range of interactive Virtual Reality worlds and exercises. The controlled distraction of stress, pain and worry gives patients the opportunity to recharge mentally without effort.

With the help of Carduso Capital and Triade Investments, VRelax can make use of more knowledge, expertise and a wider network. With the increased clout, VRelax wants to conquer a prominent place in healthcare in the field of stress reduction by means of Virtual Reality.

VRelax focuses on clients within mental healthcare, hospitals, general practitioners, nursing homes and occupational health and safety services. Together with these institutions VRelax is working on the implementation of Virtual Reality on the work floor. VRelax therefore continues to invest in research and product improvement in order to connect with the healthcare of tomorrow.


More information can be found at:

Free to use image material can be found here: www.vrelax.com/pers/

For more information please contact:


ABOUT VRELAX

VRelax is a scientifically validated app developed together with patients and professionals. It helps people with stress, pain and burn-out complaints by using Virtual Reality to reduce these complaints. The VRelax dashboard offers healthcare professionals direct insight into the effects of VRelax, and the GRIP monitoring function enables professionals to explore virtual worlds together with the patient. The healthcare sector is changing rapidly and VRelax is moving along. In combination with strong collaborations, this all-in-one solution fits in perfectly with the care of tomorrow.

Promotional video: https://vimeo.com/410534849

Carduso Capital invests in BUKU: “Making study books available to everyone, worldwide” one step closer

BUKU: the Groningen Start-Up that has developed a streaming platform, for making study books digitally available in higher education.

The investment will be used to implement the growth plans in the so-called “emerging markets” and to accelerate in the Netherlands. With the investment, BUKU can not only attract additional programmers, but also can assemble and activate more local teams in the countries where it will be rolled out.

During his studies, founder Jeff van der Laan saw on one hand that many students did not buy the expensive study books or used older versions, and on the other hand that the “purchased” study books were often not or only partially used. This results in declining turnover for publishers and in teachers and students having to improvise because the study material is not in order. With BUKU, students can, based on an affordable subscription fee, use all the study books of the platform unlimited; Universities and colleges can therefore prescribe the most up-to-date and high-quality textbooks. Publishers thereby generate stable income. Furthermore, a significant saving on raw materials and logistical costs is achieved through the digitization of study books.

By rolling out in countries where textbooks are even more priceless than in the developed Western countries, there is a contribution to the improvement of the study climate there. Central and South American countries, as well as African countries, will be the first to benefit from this. In these countries too, an earning-model is created for publishers, where they currently have limited activities.

Besides Carduso Capital, Boost-Up Groningen is co-investing in Buku.

————————————-

Website BUKU: https://buku.io

Read More

PIMS-E:

Carduso Capital invests in PIMS-E, a University of Groningen Spin-off developing an alternative for the Epipen™ via inhalation of Epinephrine by persons in a life-threatening reaction after exposure to an allergen that is dangerous to them. Think of insect stings such as from bees and wasps, food and drug allergies. The advantages of operation is the very short exposure time of dry-powder inhalation, one no longer has to give oneself an injection and the medicine has a long shelf life (and does not have to be kept in the refrigerator either).

PIMS-E did retrieve additional capital from the Carduso Capital investment fund for the development and commercialization of this Cyclops® dry powder inhalation. Dry powder inhalation is a method in which medicines are administered extremely efficiently through the lungs. The financing supports PIMS-E with the development, clinical testing and marketing of this new application.

The Cyclops® technology ensures optimum respiratory delivery of the medication in the purest form. This prevents unwanted side effects from excipients. PIMS-E sees the lungs as the ideal access to the systemic circulation for epinephrine. This route offers a number of advantages compared to the current most used application via the Epipen ™. The short exposure time and the non-invasive administration in combination with a longer shelf life at room temperature gives a greater ease of use and prevents the risk of puncture accidents.

PIMS-E is a pharmaceutical company based in Roden, The Netherlands, with in-house development and manufacturing capabilities and is established in collaboration with the University of Groningen’s Department of Pharmaceutical Technology and Biopharmacy of Professor Dr. H.W. Frijlink. Because of this unique partnership, PIMS-E possesses a skilled, enthusiastic and passionate team of researchers, pharmacists, pharmacy assistants, pharmaceutical professionals, QA/RA officials and product and process developers. For more information about PIMS-E, the director Reinier Schwietert can be contacted.

Carduso Capital is an investment firm based in Groningen, The Netherlands that participates in innovative technology companies that have strong technology links with the University of Groningen (RUG) and the University Medical Centre of Groningen (UMCG) and its affiliates. Carduso Capital believes it is important to invest in innovative companies that are early stage or at a certain moment search for capital to finance their growth. Carduso Capital supports initiatives within the main themes Life Sciences and Energy and aims for long-term cooperation’s. Besides participations with capital Carduso Capital also provides proactive management support and the use of its broad international network.

For more information about Carduso Capital: www.cardusocapital.com

Roden, Groningen, April 26 2019

For further information:

PIMS-E:
Mr. Reinier Schwietert
Tel: +31 (0) 6-51148308
Mail: rschwietert@pureims.com

Carduso Capital:
Mr. Frits Kok
Tel: +31 (0) 6-5375 1211
Mail: frits.kok@cardusocapital.com

Read More

Carduso Capital participation ‘BioBTX’ and Teijin Aramid are looking at sustainable feedstock for super fiber.

Groningen, Nederland, 30 Oktober 2018

The Japanese company, Teijin Aramid, and the Dutch BioBTX are working on a synthetic fiber made entirely of sustainable materials. The initiative that is about to start is financially supported by the provinces of Drenthe and Groningen and by Chemport Europe. Teijin Aramid has production facilities in Emmen and Delfzijl. The initiative contributes to making the industry greener. It also strengthens the position of the Northern Netherlands chemical cluster, also known as Chemport Europe.

Teijin Aramid produces super strong fibers in the Netherlands under the brand name Twaron®. In the Netherlands, the company has facilities in, among others, Delfzijl and Emmen. Their fibers are used worldwide in products that need to be made stronger, lighter and more durable. For example, in car tires, light freight containers, and protective clothing. To produce Twaron® fossil resources are used for which there are currently no sustainable alternatives.

Site Manager, Edward Groen, from Teijin Aramid in Delfzijl explains that his company wants to examine the possibility of producing a so-called bio-based version of their Twaron® fiber. “Sustainability is an important subject for us. We are focused on both sustainability improvement by the application of our products in the chain with a lighter weight and longer lifespan, and reducing our CO2 footprint during production. In production the focus is on reducing energy flows and making them more sustainable. We’re also exploring possibilities for greener raw materials. It’s fantastic to do this scouting with a partner in Groningen.”

BioBTX

To develop a green feedstock Teijin Aramid works together with the company BioBTX in Groningen. This company developed a sustainable technology that can transform renewable resources, such as biomass and residual products, into chemical resources, mainly benzene, toluene, and xylene (BTX). With the BioBTX technology, it is possible to produce these so-called aromatics in a sustainable manner and, thus, largely reduce CO2 emissions. BioBTX recently opened a pilot plant to produce aromatics on the Zernike Campus in Groningen. Based on these aromatics the chemical company Syncom will produce specific building blocks. The polymer and fibers will be made in the Research Center at Teijin Aramid in Arnhem, based on the processes in Delfzijl and Emmen.

Pieter Imhof, CEO at BioBTX, responds enthusiastically. “We have already demonstrated that it is technically feasible to make bio-based BTX and polyester. Via this path and with the renowned Teijin Aramid, we want to demonstrate that it can also be used as a raw material for high-quality applications that have very strict quality requirements!”

Carduso participation Deam receives innovation award from Mona Keijzer, state secretary for economic affairs.

On 4 October, the no. 1 Eurostars Projects of the past 3 years were presented with an innovation award during the Innovation Expo 2018 in Rotterdam.

Read More